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An assault upon the conscience of man is indicative of the “latter times.” As men depart from the faith and give heed to seducing spirits and doctrines of devils, their consciences become so weak that they show very little sign of life. The Bible describes it as a searing of their consciences with a hot iron. Initially, there is great pain in the sin and the conscience feels the pain. Yet, eventually, the conscience becomes so seared that it is numb. At that point, the conscience loses its ability to warn the believer of sin. It further loses the ability to get the believer’s attention when he is on the verge of danger. Eventually, men speak lies in hypocrisy and do not care or feel any remorse for their wickedness.
The apostle Paul knew the importance of having believers pray for him. Among the things for which he requested prayers, Paul specifically asked for prayer that he might maintain a good conscience, living honestly in all things. He did not trust the condition of his conscience to his own efforts but depended upon the Lord’s willingness to hear and answer the prayers of the saints. Unfortunately, far too many Christians have become entirely self-reliant and self-trusting. As such, fewer believers request or take part in prayer for another man’s conscience. Instead, prayer has generally been reduced to one’s needs whether they are physical, material, or financial. Scriptural Christianity places a greater concern for the conscience.
Sin within a person’s life messes with man’s conscience. It begins by attacking man’s knowledge of God with the end goal of causing a complete rejection of God. Sinful man turns to many different devices in hopes of taking care of his sin-tainted conscience. He may seek to pacify his conscience by doing religious works. He also may try to forget that his conscience has been corrupted by a further turning toward the pleasures of sin. In both cases, he is left with a conscience in need of purging. Where can man turn to find the purging he so strongly desires? According to the Bible, only the blood of Jesus Christ can purge a man’s conscience from dead works to serve the living God (Hebrews 9:14).
One important aspect of submission to the Lord involves submitting to one another. Grasping this important truth would solve many of the problems in the world, home, and church. The Bible tells us that the younger are supposed to submit to the elder (1 Peter 5:5). Husbands and wives are to submit to each other (Ephesians 5:21-22; Colossians 3:18). Christians are to submit to those who labour in the work of the Lord (1 Corinthians 16:16), and those who rule over them (Hebrews 13:17). Instead of fighting for authoritative positions, we should first seek opportunities to submit ourselves to others for the glory of God. A pride-filled heart remains the biggest stumblingblock in the way of full submission.  
The passage may appear to directly equate obedience and submission together, but each word conveys a separate and distinct concept. Although today's passage includes both obedience and submission, it is important to recognize that these two words involve separate acts. Earlier studies noted a twofold definition of obedience: first, having an attentive ear, followed by acting upon what has been said. Dividing submission into two parts helps to better understand it too (sub + mission). The prefix sub means under (thus a submarine travels under the water), and the root word mission means to be sent out. Obedience, therefore, emphasizes the act of hearing and doing, while submission emphasizes the act of placing oneself under the authority of another.