Separation is scriptural under a variety of different scenarios. Most commonly, believers understand that they are to separate from unbelievers (2 Corinthians 6:14). This does not imply that believers should not witness to the lost but that there should be no “fellowship” between the two. The Bible also indicates that there are times in which one believer should separate from another believer. Most often, this happens because of the propagation of false doctrine (Romans 16:17-18; 2 Thessalonians 3:6) or immoral practices (1 Corinthians 5:11). However, there may also be instances when believers separate for the purpose of furthering the work of God (Galatians 2:6-9).
God directs believers to submit to various authorities; yet, above all these authorities, we must submit ourselves unto God. This submission entails submitting our whole being (body, soul, and spirit) to God. Christ purchased us with His own blood on Calvary (1 Corinthians 6:20), and we are no longer our own. This means that God has the authority to tell us what to eat, where to go, what to watch, what to listen to, what to read, where to attend church, how to worship Him, and the list continues without end. Every aspect of our lives, from our thought life to our every action, remains God’s business. We should wisely submit every aspect of our lives to Him. Submitting to God enables us to resist the Devil and when we resist him, the Devil flees.
The passage may appear to directly equate obedience and submission together, but each word conveys a separate and distinct concept. Although today's passage includes both obedience and submission, it is important to recognize that these two words involve separate acts. Earlier studies noted a twofold definition of obedience: first, having an attentive ear, followed by acting upon what has been said. Dividing submission into two parts helps to better understand it too (sub + mission). The prefix sub means under (thus a submarine travels under the water), and the root word mission means to be sent out. Obedience, therefore, emphasizes the act of hearing and doing, while submission emphasizes the act of placing oneself under the authority of another.