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Two Antiochs

There are two Antioch's in the book of Acts. What are the differences between them?

The ancient world had a number of cities named Antioch. Most of them were founded by Seleucis I who ruled from 305 to 281BC. He was the founder of the Seleucid Empire that ruled from Turkey to Iran. He named the cities after his father Antiochus. As you mentioned, two of these Antioch's are in the New Testament. They are: Antioch of Pisidia - mentioned in Acts 13:14-52; 14:21. Antioch of Syria - the third largest city of the Roman empire. This city was the place where the disciples were first called Christians (Acts 11:26) and the location of the missionary sending church for Paul and Barnabas (Acts 13:1-4; 14:26-28).