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The Bible repeatedly mentions the bitterness of soul (1 Samuel 1:10; Job 3:20; Job 7:11; Job 10:1; Job 21:25; Isaiah 38:15). Job testified to speaking in the bitterness of his soul—weary of his life (Job 10:1). Hannah “was in bitterness of soul” (1 Samuel 1:10) when she spoke to the Lord concerning her desire to birth a son. Interestingly, the Book of Job contains the majority of references to bitterness of soul. It is hard to imagine any mortal man enduring more afflictions of the soul than Job. He was afflicted so deeply, he cursed the day that he was born (Job 3:1). Eventually, his bitterness of soul won out and caused him to sin against the Lord. Hannah, however, spoke to the Lord in bitterness of soul and God rewarded her for her faithfulness.
A good Bible student often incorporates many of the same tactics as a good detective. Defining Bible words involves such a task. No single verse specifically defines the word bitterness. Yet, a careful study of a few verses will help to bring the pieces together and to provide understanding. According to Isaiah, bitterness and peace are at opposite ends of the emotional spectrum (Isaiah 38:17). Proverbs associates the word bitter directly to the word sharp (Proverbs 5:4). And, lastly, the word bitter is connected to the word affliction (2 Kings 14:26, Lamentations 1:4). Using these scriptural clues, a good student will understand bitterness to be a sharp affliction. Additionally, consider the connection between the words bitter and bite, making bitterness a sharp affliction with bite. Bitterness always begins on the inside of an individual and, as we will learn, eventually works its way to the outside for others to see.
In the midst of suffering, Christians can fail to rejoice in future blessings resulting from obedience. Additionally, the trials of life can cause one to lose focus on the unseen future blessings.  One such case involves rightfully leaving vengeance to the Lord (Romans 12:19). God's blessings are frequently not seen or realized until much later. The meek who leave vengeance to the Lord have God's promise that "The LORD lifteth up the meek" (Psalm 147:6). Nevertheless, a believer living a meek life may become disheartened by those who take advantage of kindheartedness. In fact, a meek and compassionate believer may appear weak in the eyes of the world necessitating the Lord's deliverance (Psalm 76:9; Psalm 149:4). In the end, the Lord will deliver (Psalm 76:9), lift up (Psalm 147:6), beautify (Psalm 149:4), and bless (Matthew 5:5) the meek. It is important to remember that the future blessings following life's temporary trials are worth forgoing the immediate pleasures that might come from taking matters into our own hands.
The Bible repeatedly referred to Christ's meekness during His interaction with others. Meekness implies a gentle response toward those who attack. Jesus Christ demonstrated meekness to its perfection on the cross of Calvary when He said, "Father, forgive them; for they know not what they do" (Luke 23:34). Peter emphasized this point when he said of Christ, “Who, when he was reviled, reviled not again; when he suffered, he threatened not; but committed himself to him that judgeth righteously” (1 Peter 2:23). Isaiah prophesied of Christ, “He was oppressed, and he was afflicted, yet he opened not his mouth: he is brought as a lamb to the slaughter, and as a sheep before her shearers is dumb, so he openeth not his mouth” (Isaiah 53:7). The Bible says that Jesus was mocked, spit on, and struck by His accusers, yet He displayed incomprehensible meekness.